-I-PRF (own growth factors)

Regenerative Aesthetic Biostimulation

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  1. What is I-PRF and how does it work?

Fibrine for injection rich in platelets or (I-PRF) is a unique rejuvenating technique that uses the patient’s own blood plasma, enriched with:

  • Platelets (a source of healing proteins and growth factors)
  • Fibrine (wound healing and Regeneration matrix)
  • Stem cells (the healing generators of their own body and the regenerative “orchestra” of healing and regeneration molecules)

This product is injected, leading to activation of the accelerated healing and regeneration process. As a result, strong regenerative properties of the body are concentrated and fixed on the area concerned.

iPRF intensifies the functioning and reproduction of cells, having a gentle, gradual, but long-lasting effect and accumulator.

Of course, I-PRF results are also more impressive when included in a treatment plan with hyaluronic acid filling agents (fillers), wrinkle relaxation treatments and other skin treatments. There is almost no recovery period, this treatment in the clinic can be used to rejuvenate skin and hair, as well as to treat problematic melasma and scars from acne.

One of the latest applications of I-PRF is for hair loss treatment. It is used to reverse hair loss in men and women as part of a multi-stage treatment of the scalp, which is done under local anesthesia. It appears that “resets” hair follicles and reduces the impact of DHT (Dihydrotestosterone) in those with androgenetic Alopecia (hair loss model) and there is also increasing evidence that I-PRF is the new “gold standard” for Alopecia Areata.

What are the results?

  • New tissues are formed with fibroblasts, collagen and elastin
  • Improved skin and complexion elasticity
  • Pigmentation is reduced
  1. Is it the same with PRP? What is the difference between iPRF and PRP?

Both PRP (platelet-rich plasma) and PRF (platelet-rich fibrin) are treatments with platelet-derived growth factor that are extracted by centrifugation. PRF is different from PRP by the fact that there is no anticoagulant (blood thinner) added during centrifuge.

Different technical detail between PRP and I-PRF:

“The avoidance of coagulation is physiological and is achieved by negative loading of the collection tube to mimic the conditions inside our blood vessels (their lining is negatively charged), which prevents fibrin to create a clot in In their interior, thus obtaining fibrin injection rich in platelets. After injecting the PRF into the tissue turns from liquid into a gel that not only leads to filling the gaps in folds and wrinkles, but also provides a powerful regenerative matrix that releases platelet growth factors in a slow manner Physiologically controlled, tissue regeneration is a better way than in the PRP case.

In addition, the enrichment of platelets in these two products is not the same. In the PRP, platelets are enriched by two to four times more than the physiological concentrations available in the blood and there are very few circulating blood stem cells. Compared to this, the PRF contains platelets, without eliminating the strong regenerative matrix (fibrin) by adding another very rich source of growth factors and tissue regeneration: circulating stem cells in the blood.

  1. Why is fibrine important?

Fibrin works as an array that captures platelets and controls the release of growth factors “very slowly and continuously over a period of time greater than a week.” The rate of release of growth factors in the target tissue is important for tissue receptors to respond over a long period of time after treatment. “Not the amount of growth factors is the most important, but its release. To treat severe infections, antibiotics can be injected drop by drop into a intra-venous infusion, ensuring the maintenance of a stable concentration. This is also similar in PRF biology-to achieve the most important function, a stable concentration should be maintained. The most desirable process is that of an infusions drop by drop “

  1. The use of the regenerative aesthetic of PRF

Growth factors derived from plaquets trapped in a fibrin matrix are the first response to lesions observed in all human tissues. Thus, PRF applications for healing and regeneration are not limited to skin only. Accelerated healing, new blood vessels and the proliferation of collagen-producing cells (fibroblasts) have been carefully demonstrated in biomedical research investigating the basic functions of these regenerative products.

  1. I-PRF as a treatment for hair growth

This is a natural non-surgical therapeutic option for patients suffering from hair loss or thinning. iPRF can enhance the growth of hair follicles by stimulating stem cells and other cells in the hair follicle microenvironment. These special platelet cells promote healing and accelerate the rate and degree of regeneration of the tissue, resulting in new hair growth and an existing hair thickening.

  1. Faq
  • Is the treatment painful?
    The treatment will not be painful, but rather described as a minor discomfort due to the application of a local anesthetic to the skin before the start of treatment.
  • Is the treatment safe?
    Because treatment with I-PRF/PRP uses its own blood cells, the risks of adverse reaction or complications are negligible.

Dr. Hârceus uses the latest technology to get the best quality of I-PRF or PRP in the blood-we use the Closed Cellenis System® FDA approved.

  • Is there a period of convalescence after treatment?
    Usually some red spots appear in the short term, swelling and minor discomfort in the treated area, which may take several hours. Swelling in this area is less common, but if it occurs, it can be easily covered by makeup.

Most patients return to normal activities and work from the next day.

Exceptionally, a period of convalescence is needed when used to treat the lower eyelids-here patients will experience a swelling for 36 hours. This can be hidden with sunglasses, but many will choose to spend their time at home, after following treatment for the lower eyelids. The impact of I-PRF/PRP on the lower eyelid lasts about two years and can create a phenomenal result.

  • How many treatments do I need?
    This will depend on the reason for treatment. Significant skin and hair problems may require between 3 and 5 sessions to achieve the best results. These are usually performed every 4-6 days.
  • How long are the results maintained?
    The results of I-PRF/PRP therapy vary, but most are maintained up to approximately 18 months, and some up to 2 years. To help preserve the results of treatment, we recommend repetition after about 12 months.
  • What should I do before and after treatment?
    Since treatment helps you to heal naturally and stimulate regenerative capacity, avoiding known harmful behaviors-such as smoking and excessive exposure to UV radiation-is important following treatment. We also advise you to avoid taking aspirin, non-steroidal drugs (such as ibuprofen) and vitamin E supplements for several weeks after treatment and always use high-quality sun protection.
  • Is there any type of individual who cannot follow the I-PRF/PRP treatment?
    If you are applying any of the following health situations or conditions, it would not be appropriate to follow PRP therapy.

    • Pregnant or breast-feeding
    • You are under treatment with an anticoagulant, such as warfarin
    • Any condition that has a significant effect on platelet function;
    • Haemodynamic instability
    • Sepsis
    • Acute or chronic infections

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